TotalBio is an intensive 8-week training program that prepares aspiring medical device sales professionals for immediate success in the biologics industry. Students build a strong foundation in anatomy, pathology, and tissue biology, then apply that knowledge directly to orthopedics, sports medicine, wound care, plastics, and dental/maxillofacial use cases.
Designed and taught by industry experts, TotalBio delivers specialized biologics expertise, advanced sales training, and real-world market insights that give graduates a competitive edge. Through role-plays, case studies, and territory planning, students learn how to communicate clinical value, navigate hospital and OR environments, and confidently position biologic solutions for adoption.





All medical sales representatives must complete industry credentialing prior to entering the operation room.
Professional Representative Certification (PRC)
As a requirement, all medical sales representatives must complete industry credentialing prior to entering an operating room. Knowing hospital protocol and operating room etiquette is a must. Most company sponsored training programs spend less than a day covering this subject matter. At the Medical Sales College, we offer the best-trained professional representatives for the benefit of the employer, hospital and patient safety. In addition, as a selling representative, you work with several departments at the hospital. In our PRC certification, a student of the Medical Sales College takes it a step further. A typical representative learns by trial and error. At the Medical Sales College we want to give you every advantage to succeed. We take no chances. Outside of hospital protocol and operating room etiquette, we also cover industry regulations.
This module covers the scientific and clinical foundations of biologics, including bone anatomy, cellular and signaling mechanisms in bone healing, and common orthopedic and dental bone pathologies where biologic therapies are applied.
Develop a comprehensive understanding of biologic principles related to how orthopedic tissues heal including detailed instruction related to bone and cartilage grafting, tendon & ligament repair, wound care, and many other invasive and non-invasive biologic alternatives and adjuncts used both in clinic and in the surgical setting. Dynamic Consultative Sales (DCS) methods will be layered in throughout the weeks of biologics instruction in preparation for the final week on-campus.
Students explore bone anatomy across orthopedic contexts, comparing cortical and cancellous structures and understanding how bone supports both mechanical load and biologic function. Cellular biology (osteoblasts, osteoclasts, osteocytes), key signaling pathways (BMPs, RANKL, VEGF), scaffolds, and mechanotransduction are linked to the stages of bone healing and Wolff’s Law. The module concludes with common bone pathologies: fractures, osteoporosis, osteoarthritis, spine conditions, and dental bone loss, framed as clinical opportunities where biologics play a role in treatment.
This module focuses on real-world bone biologic products, comparing graft types and growth-factor materials while introducing regulatory pathways, safety and handling standards, and ethical considerations that influence product selection in clinical practice.
Students move from scientific principles to real-world biologic product applications. This module covers all major categories of bone grafts, including: autograft, allograft (DBMs and CBMs), synthetics, growth-factor–based products, and hybrid synthetic/xenograft materials. Students compare composition, handling characteristics, use cases, and strengths/limitations. Regulatory pathways (HCT/P, 510(k), PMA, BLA), CE Mark considerations, donor screening standards, sterilization methods, preservation techniques, chain-of-custody procedures, and implant tracking are incorporated to build regulatory literacy. An ethics component highlights cultural, religious, allergy-related, and comorbidity-based factors that influence biologic product selection in clinical practice.
This module focuses on the structure, function, and vulnerabilities of cartilage as a target for regenerative technologies.
Students study the composition of articular cartilage, fibrocartilage, and related tissues, then explore joint-preservation pathologies such as osteoarthritis. Emphasis is placed on understanding how cartilage degeneration guides treatment decisions and where biologic solutions—including scaffolds, grafts, and adjunctive regenerative therapies—fit into clinical pathways in sports medicine and orthopedics.
Students examine the biologic and mechanical properties of soft tissues, including tendons, ligaments, and skin.
This module explores tissue composition, key cell types (fibroblasts, keratinocytes, melanocytes), growth signals (PDGF, FGF, VEGF), and scaffold elements (collagen, elastin, proteoglycans). Learners study the phases of soft tissue healing and principles such as mechanotransduction and Davis’s Law. Common injuries: sprains, strains, partial and complete tears, are reframed as clinical problems that create demand for biologic interventions, preparing learners for product-focused discussions in the next module.
This module covers biologic and graft-based solutions for tendon, ligament, skin, and dental soft tissue repair.
Building on the science from Module 4, students explore the biologic and graft-based solutions used across tendon, ligament, skin, and dental soft tissue procedures. This includes birth tissues (amnion/chorion, umbilical cord, Wharton’s jelly), autograft and allograft skin, xenograft options (fish skin, bovine tendon), and cartilage grafts. Applications span orthopedics, sports medicine, trauma, and other tissue regeneration. The module also covers PRP and BMC as adjunct therapies. Ethical and clinical considerations: religion, culture, allergies, and patient comorbidities are integrated to help students engage confidently and compliantly with clinicians.
This module explains wound healing phases, chronic and acute wound types, and the biologic interventions used in wound care, preparing students to understand treatment pathways and collaborate with multidisciplinary clinical teams.
Students learn the biologic and clinical principles behind acute and chronic wound management. This module breaks down the phases of wound healing—hemostasis, inflammation, proliferation, and remodeling—and explores how impaired healing drives the need for biologic interventions. Learners examine wound types (partial thickness, full thickness, chronic wounds) and the biologic solutions used in treatment pathways, including bone grafting in complex defects and soft tissue grafting for coverage and regeneration. The module prepares students to understand the rapidly growing wound care biologics market and communicate with multidisciplinary care teams.
This module focuses on how biologics are sold, supported, and evaluated within clinical settings.
Students explore market segments (bone, soft tissue, adjunct therapies, wound care), positioning strategies (standalone, cross-sell, loss leader), and day-to-day responsibilities of biologics representatives. The intraoperative sales section covers hospital and ASC environments: contracting processes, VAC meetings, GPO/IDN considerations, RFI/RFP workflows, ordering, shipping, and consignment management. The in-office section highlights patient-facing conversations, reimbursement basics (Medicare, Medicaid, commercial carriers), documentation requirements, and rebate programs. Students learn how to blend clinical credibility with strong commercial strategy.
In this capstone week, students refine and demonstrate their clinical, communication, and sales competencies through immersive hands-on activities.
Role-plays, mock sales calls, biologic product demonstrations, case studies, and territory planning exercises allow students to apply their knowledge in realistic scenarios. The employment readiness component includes resume refinement, LinkedIn optimization, interview simulations, and a structured job search strategy tailored to biologics, regenerative medicine, and wound care roles. Students finish the program fully prepared to enter the job market and begin leveraging MSC’s career placement services.
There's a certain level of finesse, there's a certain level of professional knowledge necessary. You have to look at an x-ray and help the doctor figure out treatment. You have to help a surgeon, as you're standing in the OR, figure out how to use your product while they're using it on a patient."
Venus Concept
...you're going to gain so much knowledge, so much experience. You're going to be blown away with what you don't know walking in. Do I have any regrets? I wish I would've done this 3 or 4 years ago."
Squared Circle Medical LLC
From day one I knew that Medical Sales College was exactly what I was looking for and I felt an immediate connection with the subject matter and the professors. It was the perfect amount of challenging and intriguing which kept me motivated and stimulated throughout the program."
Smith + Nephew
TotalBio is an advanced 8-week program in one of the fastest and most innovative fields of medical sales. It is a fully online program, an ideal path for those seeking flexibility without sacrificing growth or earning potential.
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Medical Sales College is licensed and operating as Med Sales Institute in CA – DE – FL – GA – TX
Medical Sales College is licensed and operating as Med Sales Institute in CA – DE – FL – GA – TX